![]() ![]() ![]() Lufenuron is another active ingredient in Sentinel ® and Sentinel Spectrum ®. By overloading chloride into these worms, it affects the electrical activity within their nervous system, causing muscle paralysis and death. Milbemycin shifts chloride, a naturally occurring electrolyte, across the cell membrane of certain susceptible worms such as heartworms, roundworms, whipworms and hookworms. The main active ingredient in both Sentinel ® and Sentinel Spectrum ® is milbemycin oxime. Sentinel Spectrum ® is intended for dogs and puppies weighing more than two pounds and older than 6 weeks of age. Sentinel Spectrum ®contains the same active ingredients as Sentinel ®, along with the addition of a third ingredient, praziquantel, to provide the additional benefit of preventing and controlling tapeworm infections. It is indicated for adult dogs and puppies weighing more than two pounds and older than 4 weeks of age, for the prevention of heartworm disease, for the prevention and control of flea populations, the control of adult hookworms, and the removal and control of adult roundworms and whipworms. Sentinel® contains two active ingredients, milbemycin oxime and lufenuron. This content shouldn’t take the place of advice by your vet. PetMD’s medications content was written and reviewed by veterinary professionals to answer your most frequently asked questions about how medications function, their side effects, and what species they are prescribed for.
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